Summary:
In adult patients with type 1 diabetes good metabolic control was associated with
an undesired weight gain. In the present report the possible association of HbA1c
and body mass index (BMI) in children and adolescents with type 1 diabetes (IDDM)
was investigated in a long-term retrospective study from 1976 to 1995. Further, the
relationship between BMI on one hand and age, gender, duration of IDDM, the number
of units of insulin used and the number of injections per day on the other hand were
considered. Statistical analysis was performed using repeated measurements analyses
of variance.
The 208 girls and 201 boys were 5-17 years old and had diabetes for beyond one year.
For analysis 2512 data sets, in part measurements on the same patient in the course
of the disease, were available. In various statistical models, the results show that
age, gender, the daily amount of insulin, and the HbA1c level (p < 0.001-0.005) were
associated with the BMI. Extremely high HbA1c levels coincided with a remarkably low
BMI.
Hence, in children and adolescents with IDDM it may be difficult to achieve a constantly
good metabolic control accompanied by a normal body weight.
Abbreviations: BMI = body mass index, z-score = SDS = standard deviation score, DCCT = Diabetes
Control and Complications Trial
Key words:
HbA1c - BMI - insulin - children - adolescents
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Josef HögelPhD
Department of Biometry
and Medical Documentation, University of Ulm
D-89069 Ulm
Phone: +49 731 50 26895
Fax: +49 731 50 26902
Email: josef.hoegel@medizin.uni-ulm.de